Our results also showed that comorbid anxiety disorders or depression, as well as substance use disorders, had a strong influence on the risk of premature death among persons with OCD. In particular, comorbid substance use disorders were observed to increase mortality risk to a large extent. However, the excess mortality observed to be associated with OCD was only partly explained by these comorbid conditions. The mortality rate was still increased by almost 90% among persons with OCD only compared with those persons without OCD (MRR, 1.88), when we excluded persons who received a comorbid diagnosis of anxiety disorder, depression, or substance use disorder.
