The SNP-based heritability of alcohol consumption in the total sample was estimated to be 0.13 (s.e.=0.006, P=1.3 × 10−119). The SNP heritability in males was estimated to be 0.15 (s.e.=0.01, P=2.3 × 10−41) and in females 0.13 (s.e.=0.01, P=8.1 × 10−36). The SNP heritability in males was not significantly higher than in females (Z-score=1.43, P-value=0.152). The SNP-based genetic correlation between male and female alcohol consumption using LD score regression was 0.9 (s.e.=0.09, P-value=7.16 × 10−23), suggesting that the genetic factors influencing alcohol consumption in males and females in this sample were largely, but not completely, overlapping.
