Chunk #165 — V. “Generalization” of selected genome wide association results between related disorders and phenotypes — I. Failure of control experiments to support alternative hypotheses for the observed genome wide association results
Finally, comparisons with data from a complex phenotype outside the brain provide a useful contrast with the observed congergence identified in the datasets above. Data for type I diabetes from the Welcome trust case control consortium provide such a contrast [1]. Using Monte Carlo simulation approaches identical to those used to identify the highly significant overlaps noted above, we identify no significant overlap between genes that contain clustered, reproducibly nominally-positive SNPs for substance dependence (samples 1 and 2) and genes that are identified in similar fashion for type I diabetes (C J and GRU, unpublished observations, 2007).
