However, future research will have to demonstrate if a fully human co-culture system can be used with patient iPSC-derived astrocytes and neurons and whether impaired functional networks can be reversed using compounds or gene editing technologies. Furthermore, the interaction between human astrocytes and neurons could be studied by culturing diseased astrocytes with healthy neurons or vice versa. Finally, by adding human iPSC-derived or primary microglia, a triple co-culture model could eventually be a tool to study neuro-inflammation.
