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Chunk #13 — MATERIALS AND METHODS — Phenotypic and genetic correlation analyses

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Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry.
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We examined two distinct types of correlations: phenotypic correlations, where both variables were measured in the same individuals, and genetic correlations, where we used AUDIT data from this cohort in conjunction with summary statistics for GWAS conducted in other cohorts (Supplementary Table 9). The interpretation of these is different, since phenotypic correlations can be due to a combination of genetic and non-genetic factors, whereas genetic correlations measure only genetically driven correlations.