Our largest PTSD meta-analysis in subjects of EUA (maximum number of subjects included in EUA meta-analyses: N = 23,212 cases, 151,447 controls, see Table 3 for details) identified two independent, genome-wide significant loci (P < 5 × 10−8), both mapping to chromosome 6, and sex-stratified analyses in men identified two additional loci (Fig. 1a, b, respectively). The smaller meta-analyses in AFA (N = 4363 cases, 10,976 controls) identified one genome-wide significant locus, and an additional locus was found in men when stratified by sex (Fig. 1c, d, respectively). No genome-wide significant associations were found in meta-analyses of EUA or AFA women (Supplementary Fig. 3).Table 3Meta-analyses of European (EUA) and African (AFA) ancestry GWASSubjectsVariantChrA1A1 freqBetaSEOR95% CIP-valueN casesN controlsN effective# sign. markers I 2 Q N studies EUA Allrs345178526a0.340.1100.021.121.08–1.163.1 × 10−912,08033,44630,274*414.230.2241 Allrs93646116t0.13−0.1240.020.880.85–0.924.3 × 10−823,212151,44770,33210.000.6043 Menrs57184866219t0.61−0.1390.020.870.83–0.917.8 × 10−9626322,97116,964*10.000.8331 Menrs1487573211ctgtg0.830.1680.031.181.11–1.263.7 × 10−8**626322,97116,964*226.160.0931 AFA Allrs11553997813t0.070.2840.051.331.20–1.472.7 × 10−8436310,97611,3221013.950.2821 Menrs1421745236a0.30−0.2770.050.760.69–0.844.3 × 10−8**17825361470210.000.7613Leading markers for genome-wide significant loci (at p < 5 × 10−8) in the overall and sex-stratified analyses are reported. The imputation information score ranges from 0.64 (rs34517852) to 1.16 (rs115539978), with a median score ranging
