Chunk #13 — Methods — Measures — Genotyping and Externalizing Polygenic Scores.

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Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use.

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In order to account for population stratification, we regressed all polygenic scores on the first 10 genetic ancestry principal components (PC1-PC10) and saved the residualized PGS. Analyses were conducted separately by ancestral background. We used standardized, residualized polygenic scores in all subsequent analyses.