et al., 2004). Once such local circuit reconstruction is accomplished, then adjunctive approaches such as olfactory ensheathing cell (Granger et al., 2012) and glial progenitor cell delivery (Buchet et al., 2011; Kawabata et al., 2016; Mozafari et al., 2015), respectively designed to generate peripheral and central myelin and hence improve conduction within locally-restored networks, may be productively deployed to potentiate recovery. Indeed, the need for multimodal biological therapies in SCI is highlighted by the additional benefit potentially gained by combining cell transplantation with matrix-modifying enzymes so as to facilitate donor cell integration (Ikegami et al., 2005).
