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Chunk #27 — Results — Subjective response measures during cumulative alcohol dosing procedure

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Independent and Interactive Effects of OPRM1 and DAT1 Polymorphisms on Alcohol Consumption and Subjective Responses in Social Drinkers.
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There was a significant main effect of alcohol across time for the POMS tension and anxiety subscale (F7, 856 = 3.05, p=0.004), BAES sedation (F7, 856 = 34.02, p<0.001), BAES stimulant (F7, 856 = 24.46, p <0.001), DEQ VAS positive (F7, 856 = 61.29, p<0.001), DEQ VAS negative (F7, 856 = 21.44, p<0.001), and SHAS scores (F7, 856 = 80.39, p<0.001). Mean DEQ VAS positive effects, BAES stimulation and SHAS scores increased progressively after the each alcohol drink, and peaked after consumption of all 3 alcohol drinks (135 min) when BAC peaked (0.1%). Mean DEQ VAS negative subjective effects, and BAES sedative scale scores increased and peaked on the descending limb of the BAC (270 min).