Prior knowledge of karyotypes characteristic of a particular disease is summarized as a mixture of K multivariate multinomial distributions over the integer homologous copy-states Q = [0,7] of each chromosome arm. For a given candidate purity and ploidy solution, the corresponding segmental copy-state indicators for each segment i, q̂ij, are summarized into estimates of the J arm-level homologous copy-numbers, denoted Ĉ. The karyotype log-likelihood score is calculated as:
