We recently identified association of allele T of rs157935, located at 7q32 (Figure 3), with basal cell carcinoma (OR = 1.23, P = 5.7 × 10−10)7. Limiting the analysis to samples for which parental origin could be determined, the paternally inherited allele was significantly associated with the disease (OR = 1.40, P = 1.5 × 10−6), but the effect of maternally inherited allele, while in the same direction, was not significant (OR = 1.09, P = 0.19) (Table 1). Tested directly, the effects of the paternally and maternally inherited alleles were significantly different (P = 0.010).
