Alcohol dehydrogenase 1C (ADH1C) is another widely studied gene related to alcohol metabolism. Meta-analysis indicated an association between the protective ADH1C allele (in SNP rs698, referred to as ADH1C*2) and lower consumption and/or AUDs (Li et al., 2012). As with ADH1B, this association is found more consistently in East Asians (Li et al., 2012) than non-Asians (Zintzaras et al., 2006; Tolstrup et al., 2008; Toth et al., 2011; Olfson & Bierut, 2012). Earlier work on rs698 in Jewish Israeli samples found no association with consumption (Neumark et al., 1998), or alcohol elimination rates (Neumark et al., 2004), perhaps due to low power to detect associations in small samples. In addition, these studies did not examine AUDs. Therefore, investigation of rs698 and multiple alcohol phenotypes in non-Asian populations is warranted.
