We also did a meta-analysis that excluded related individuals from the family-based samples of the Psychiatric Genomics Consortium, using an inverse variance-weighted scheme, to generate summary statistics that produced effect sizes for use in follow-up analyses (14 080 cases, 343 726 controls). A transancestral meta-analysis using METAL23 combined results across the European and African ancestry cohorts, comprising 20 916 individuals with cannabis use disorder (17 068 from European ancestry, 3848 from African ancestry) and 363 116 controls (357 219 from European ancestry, 5897 African ancestry; appendix pp 13–14, 17). Conditional analyses were done in GCTA-COJO24 by conditioning the meta-analysis summary statistics on the lead variants of genome-wide significance.
