interaction in the impact of GABRA2 variants and risk for AD. Other studies have reported association between AD and GABRA6 22–24, GABRB3 and severe alcoholism 25 and Song et al 24 found evidence of association with GABRA5 and GABRB3. The most frequent combination of GABAA subunits is α1, β1, and δ 26. Of these three common subunits, only β1 and δ were sampled on the array, but when SNPs for these the genes encoding these subunits were considered together as a group they also reached a significance level of 0.025.
