in patients. In our data, significantly elevated expression was observed for several MAPK encoding genes (MAP3K2, MAP3K7 and MAP3K6) and related factors (JUN, PRKCD, HOMER3 and MYH9). In addition, expression levels of upstream regulators for the PI3K/AKT signaling pathway, PIK3C2A and PPM1F, were increased as well. These results suggest that disruption of the MAPK signaling cascade in 22q11.2 SZ neurons might result in prolonged cycles of cell division and cell proliferation, and enhanced cell death through apoptosis during neuronal differentiation.
