We compared our fine-mapping results to two previous studies. First, we compared our results to ref. 12, which performed non-functionally informed fine-mapping for 9 blood cell traits using approximately 115K of the individuals included in our analyses. PolyFun + SuSiE identified 4.4× more SNPs than ref. 12, including all four SNPs that were functionally validated via luciferase reporter assays in ref. 12 (PIP>0.999 for all four SNPs; Methods, Supplementary Table 18–20). Second, we compared our results to ref. 7, which performed non-functionally-informed fine-mapping for 7 of our traits, using a non-functionally informed method (PICS) and independent smaller data sets. PolyFun + SuSiE identified 35x more SNPs than ref. 7; Supplementary Tables 21–22). Further details of the comparison are provided in the Supplementary Note.
