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Chunk #31 — Discussion

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Heritability of level of response and association with recent drinking history in nonalcohol-dependent drinkers.
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This analysis demonstrated that among non-alcohol dependent drinkers, LR is heritable, and has an inverse relationship with the amount of alcohol consumed and drinks per drinking day. There were a few limitations to the present study. This study was an evaluation of retrospective measures of drinking history as well as self-reported measures of LR across individuals collected at a single point in time. Longitudinal evaluations of cohorts of young individuals, assessed for their level of response to alcohol as young adults and then followed over 5 to 25 years, have shown consistent relationships between level of response and development of alcohol use problems (Schuckit et al., 2007; Trim et al., 2009). Future research may involve following the present cohort of participants to determine if any develop alcohol use disorders. A second limitation was the reliance on participants’ recall of individual and family history of alcohol use. As mentioned above, even though the sample size was relatively larger than previous studies, an even larger sample size may reveal a heritable association of LR with regular alcohol consumption. Participants were randomly recruited,