We used Cytoscape software18 to identify 228 genes within two degrees of relation to eight GRM genes based on the merged human interactome. We clustered this network of genes into 17 distinct modular clusters based solely on network topology using the ClusterViz plugin for the software using the FAG-EC algorithm with default parameters. Component genes in each of the 17 modules were submitted to DAVID58 to assess the significance of functional enrichment using Homo sapiens Gene Ontology annotations.
