We compared our data with replicated candidate-gene studies, which were derived from (19), as well as the recent GWA reports that implicated intergenic intervals at the 5p14.1 CDH9–CDH10 and 5p15.2 SEMA5A–TAS2R1 loci, respectively (20,21,24) (Supplementary Material, Tables S5 and S6). Because the estimated effect sizes for these studies typically fall in the range of 1.1–1.3, our power to replicate these findings was low (Supplementary Material, Fig. S4) and some of the prior candidate-gene studies made use of markers not well tagged by SNPs in our study. We found some support for several prior candidate loci, including CNTNAP2, RELN and SLC25A12 (P < 10−4), but our analysis did not garner additional evidence for either of the top findings from the prior GWA studies.
