In summary, there appears to be relatively well-developed evidence that brain connections between the left OFC/VM PFC and the amygdala contribute to the inhibition of actions in response to immediate, affectively felt needs, when those actions conflict with individuals’ long-term interests and goals. It appears that low levels of 5HT and resulting high levels of DA in this pathway may reduce this useful function, resulting in higher rates of rash actions in response to current emotions. It may be the case that the presence of certain alleles in the 5HT transporter gene and in three DA receptor genes contributes to low 5HT and high DA levels.
