(problematic experiences at work and with one’s spouse, children, and friends) and uplifts (pleasurable experiences across the same categories). They found that males who had the high-risk GABRA2 genotype, as indicated by having one or more copies of the A-allele at rs279871, and who experienced more daily uplifts had a lower probability of alcohol dependence compared to males who had the high-risk genotype and who experienced fewer daily uplifts. In contrast, the probability of alcohol dependence for females did not differ as a function of either their genotype or the number of uplifts experienced. This suggests that an environment characterized by these types of social support mitigate the alcohol dependence risk associated with the A-allele for this variant for males, but not females.
