The purpose of this study was to combine the power of RI strains of mice and a systems genetics approach to explore the role of Cd14 in ethanol responses using two sets of existing hippocampal gene expression data that we generated. In this study we sought to identify expression quantitative trait loci (eQTL) for Cd14, analyze potential pathways through which Cd14 interacts with ethanol, and construct a genetic network that plays a part in ethanol responses.