significant impact (Mayfield, Harris, & Schuckit, 2008). It is also plausible that effects seen from specific SNPs vary from patient to patient due to each individual’s unique genetic background. This suggests that the risk factors for the development of an AUD are quite complex and necessitate the use of a technology capable of modeling both its complex genetic underpinnings. Furthermore, human pluripotent stem cells enable the use of gene editing technologies to more directly isolate the precise cellular phenotypes of a SNP.
