Sensation-seeking has been associated with substance use risk (Malmberg et al., 2010), and high alcohol use (Schall et al., 1992; Sher et al., 2000). Here we report no differences by familial risk in sensation-seeking levels, drinking volume, reward task performance and anticipatory striatal activation in young adults. However, we observed group differences in reward-related functional connectivity with the NAcc that influenced the relationship between personality and drinking outcome in the high-risk population.
