quality variants available for analyses. Comparisons of subject-level genotype discordance for overlapping SNPs between the 1000 Genomes Phase 1 imputation, the MIS imputation, and whole genome sequencing (WGS) found an average discordance of 0.7% for MIS and 2.5% for 1000 genomes Phase 1 against WGS across all 22 chromosomes. This is a non-trivial increase in imputation quality and highlights nearly seven years of scientific improvement in the area of genomic imputation.
