Chunk #44 — Methods — Estimation under the LCV model

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Distinguishing genetic correlation from causation across 52 diseases and complex traits.

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Fourth, we define a collection of statistics S(x) for x ∈ X = {−1, −.01, −.02,…,1} (corresponding to possible values of gcp): (7)S(x)=A1(x)−A2(x)max(1∣ρg∣,A1(x)2+A2(x)2)whereAk(x)=∣ρg∣−xκ^k.