A series of analyses was conducted to determine whether withdrawal and craving changed after abstinence or cue exposure, whether subjective effects and HR changed after marijuana administration, and whether these changes were associated with FAAH C385A variance. The analyses of the effects of abstinence and cue exposure utilized 2 (Trial: Pre- vs. Post-Abstinence or Pre- vs. Post-Cue Exposure) × 2 (Genotype: FAAH C/C vs. A/C and A/A) mixed analyses of variance (ANOVAs), where Trial was a within-subjects factor, and Genotype was a between-subjects factor. The analyses of the effects of marijuana utilized 2 (Trial) × 2 (Genotype) mixed analyses of variance (ANCOVAs), with baseline scores on the outcome measures co-varied, where Trial was a within-subjects repeated factor, and Genotype was a between-subjects factor. The baseline score co-varied for each outcome measure was the score recorded after cue exposure, to avoid conflating cue-induced effects. Results were deemed significant at p<0.05.
