these depletions were, however, more attenuated (Fig. 2b, Extended Data Fig. 7). Additional assessment of the site frequency spectrum showed that, as deletion sizes increase, these SVs become rarer (P < 2.2 × 10−16; linear model, F-test), evidence of purifying selection against events more likely intersecting functional elements. Duplications, by comparison, did not exhibit such trend, consistent with reduced selective constraints (Supplementary Note).
