insulin stimulated skeletal muscle glucose uptake but also normalized the rate of insulin stimulated glycogen synthesis in this tissue to that seen in the lean Zuckers (Table 7), albeit at a higher insulin level. The effects of tesaglitazar on augmenting insulin mediated control of hepatic and skeletal muscle glucose metabolism are consistent with the results of a number of studies with other PPARγ agonists on glucose metabolism in both animal models [31] and even patients with type 2 diabetes [32].
