of the STAT3 module in oligodendrocyte precursor cells (OPC,FDR < 0.036; Fig. 5b). Several of the predicted NFKB1 gene targets were also differentially expressed including the inhibitor of this pathway, NFKBIA (log2FC = 1.86, FDR = 0.039; Fig. 5e). Other glial cell types showed non-significant activation of this module, with the weakest being microglia. In response to cell stress, microglia release pro-inflammatory cytokines that may trigger an interferon response in other cell types, potentially responsible for broader patterns of interferon activation we observe across multiple striatal cell types in OUD84.
