Chunk #4 — INTRODUCTION

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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Genome-wide studies of lung cancer report strong association with rs16969968 and its r2 correlates [16, 21–23]. The locus tagged by rs578776 is also associated with lung cancer. Thus there has been a convergence of genetic findings for nicotine dependence and for lung cancer.