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Chunk #48 — Methods — DEPICT Functional Analysis

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Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
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We utilized DEPICT18 to determine the most likely causal gene at each of the depression-associated loci, and to assess reconstituted gene sets enriched for and tissues highly expressing those genes. The reconstituted gene sets used in the analysis are derived from publicly available gene set annotations, which are then integrated with 77,840 gene expression arrays36 to predict which other genes are likely to be part of these gene sets.