In addition to the substantive relationship of our prior examination of parent monitoring there is a statistical consideration for the current study. Taking a broader perspective of correcting for multiple tests, results should be considered within the context of the number of tests done using a sample as a whole [35]. Having tested two hypothesized GxE interactions in the COGEND sample prior to the current study [33] plus the four tested here would lower the strict Bonferroni corrected p-value to 0.0083 (0.05/6). As the p-value for the H.S. peer smoking by rs16969968 interaction was 0.0077 this stricter correction does not alter this study’s conclusions.
