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Chunk #31 — Discussion

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Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.
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In summary, our study shows that NRG1 is probably a susceptibility gene for CaD, based on convergent evidence of linkage and replicated associations in two independent samples of AAs. Further studies using a high density SNP panel or deep sequencing are necessary to confirm the role of NRG1 in CaD.