protein complex binding (Fig. 2C), with their cellular component enrichment observed in the MHCII protein complex (Fig. 2D). Notably, a higher expression level of “chromosome separation” genes in the high-PRS microglial cells was observed when compared with low-PRS microglial cells (Fig. 2E). Also, we noticed lower expression levels of genes belonging to the “antigen processing and presentation” terms in AUD low-PRS cells (Fig. 2F). There was, as expected, considerable variability among individual lines.