We checked normality for continuous variables. All subjective response variables were skewed, particularly in the placebo condition due to infrequent nonzero response, and efforts to log transform these variables were not successful as the variables remained heavily skewed following these transformations. As a result, all outcomes were analyzed using a nonparametric approach for repeated measures (Brunner et al. 2002) in which data were first rank-ordered, then fitted using a mixed effects model with unstructured variance-covariance matrix and p-values adjusted for ANOVA-type statistics (ATS). Primary outcome variables were self-reported stimulation and sedation on the BAES. We utilized separate models to predict each. All models included three predictor variables and their interactions: 1. self-reported impulsivity; 2. ethanol dose condition (high dose, low dose or placebo); and 3. time (7 timepoints: +10, +30, +60, +110, +140, +170 and +230 min.). Dose and time were within-subject variables. Timepoints were anchored to the time when target BrAC was first achieved. For instance, the +10 timepoint occurred 10 minutes after target BrAC was reached, approximately 30 minutes after IV ethanol infusion began. Given that this nonparametric
