The US Preventive Services Task Force has recently recommended screening for unhealthy alcohol use among adults in primary care settings as well as the provision of behavioral counseling interventions.30 Similarly, the American Society of Clinical Oncology recently published a statement on alcohol and cancer providing guidance for reducing the disease burden.31 Stronger alcohol regulations have been associated with lower alcohol consumption, less binge drinking, and lower rates of mortality from alcoholic cirrhosis.32 However, in the case of both screening22 and regulation,32 appropriateness and utility of interventions may vary with racial/ethnic and regional differences, in accordance with underlying risk factors, cultural factors, and health care provision disparities, demanding the deployment of sophisticated and culturally aware interventions.33