The most significant association results were with variants on chromosome 11 in COGA-AA+EA (most significant: rs10647170, p=3.53E-09), with both subsamples providing supporting evidence for the association. Evaluation of rs10647170 in independent datasets provided nominal evidence of replication in the NIAAA-AA (p=0.05), but not in the SD-EA or NIAAA-EA (Table 3) samples. Meta-analysis of COGA-EA+AA and the 3 replication datasets resulted in a lower p-value of 6.45E-10.
