We in silico predicted the incidence of known transcription factor binding sequences (TFBSs) at the promoters of both gene types, using the HOCOMOCO [33] human TFBS models database. We found 74 TFBSs overrepresented in protein-coding gene promoters and 140 TFBSs overrepresented in lncRNA gene promoters (“differentially enriched in lncRNA promoters”) (Table S2).
