It is likely that NOGO P3 generation involves activation of a network of brain regions associated with inhibitory behavior. θ frequency oscillations in the EEG have been shown to relate to long-range synchronization (e.g., fronto-parietal) systems as opposed to higher frequencies that appear to reflect short-range networks (von Stein and Sarnthein 2000). There is further evidence to suggest that large networks can be recruited during slower frequency activity (Buzsaki and Draguhn 2004), which is consistent with our finding that δ total power related to measures of white matter microstructural integrity in pathways, including the cingulate bundles, linking frontal to parietal cortical regions.
