Table 1 shows the odds ratios from the logistic regression analyses for MDD and comorbid disorders. In our full case–control sample, we found that increasing the neuroticism score by one standard deviation (s.d.) carries an odds ratio for MDD of 1.37. In our case sample, we also found that higher neuroticism scores significantly increased the risk of all comorbid disorders examined. For each s.d. increase in neuroticism, the highest risk increase was for generalized anxiety disorder (OR = 1.13) and the lowest was for phobia (OR = 1.06).