The ten variants with the smallest experiment-wise P values of association of allele frequency with heroin addiction in Caucasians and African Americans are listed in Tables 2 and 3, respectively. The variant rs10494334 (located at 1q23.3) had the smallest point-wise P value (P = 0.0003) for association of allele frequency with heroin addiction in the Caucasian group, and this association was significant experiment-wise when corrected for multiple testing (P = 0.035) (Table 2). An in-depth analysis of this intergenic variant and surrounding sequence revealed no annotated gene within 100,000 nucleotides or any indication of this variant altering known or predicted function. Variant rs2323218 was ranked second by ascending P value and is located 8,989 nucleotides downstream of the T gene, which codes for an embryonic nuclear transcription factor (point-wise P = 0.0003) (Edwards et al., 1996).
