reporter assay constructs which included rs4950. One pair of constructs extended approximately 3000 bp upstream of the initiation codon of CHRNB3 and included SNPs rs13277254 and rs13277524. Both of these SNPs are among the top five SNPs (rs10958726, rs1955186, rs1955185, rs13277254, and rs13277524) in high linkage disequilibrium showing similar levels of nominal significance (p<0.01). The other pair of constructs included SNPs rs6474413 and rs4950, which were among the “second-tier” level of significant SNPs (Table 2).
