COGA (ORALCP-total = 1.20–1.27, ΔR2 = 0.65–1.26%). Additionally, the ALCP-total PGS was associated with cannabis use disorder criteria in both COGA and Add Health (βALCP-total = 0.11–0.16, ΔR2 = 0.26–0.31%), and nicotine dependence criteria in COGA (βALCP-total = 0.20, ΔR2 = 0.45%). However, the ALCP-specific PGS was only associated with ever using illicit substances (other than cannabis) and the associations are attenuated compared to that of ALCP-total (ORALCP-specific = 1.12–1.15, ΔR2 = 0.33–0.44%).
