Given a P value threshold specified by the user, COJO14 is a method that identifies a set of SNPs such that, in a multivariate regression of the phenotype on all the SNPs in the set, every SNP has a P value below threshold. COJO uses the meta-analysis summary statistics together with LD estimates from a reference simple. Our COJO analysis was conducted using a reference sample of approximately unrelated individuals of European ancestry from UK Biobank. We specified the P value threshold 5 × 10−8. The analyses were restricted to SNPs satisfying recommended quality-control filters. The Supplementary Note contains additional details.
