that exceeded the genome-wide threshold for significance (P < 5 × 10−8; Manhattan plot in Fig. 1, regional association plots and forest plots in Supplementary Figs. 231, and a list of all independent genome-wide significant SNPs in Table 1 with additional details in Supplementary Tables 2 and 3). The independence of the 30 lead SNPs was subsequently validated using conditional and joint analysis (GCTA-COJO)14 (Supplementary Table 4). An analysis of the X-chromosome, conducted in a subset of the data for which this information was available (23andMe), yielded no significant associations (Supplementary Note 4 and Supplementary Figure 37e). Of the 15 genome-wide significant loci previously reported in preprints12,13, 13 were genome-wide significant in the current GWAS, with the remaining two showing suggestive significance (P = 5.23 × 10−8 and P = 2.2 × 10−7; Supplementary Table 5). Using MiXeR15, we estimated that approximately 11,500 (s.e. = 607) causal variants account for 90% of the OCD SNP-based heritability.
