fatty acids (Cravatt and Lichtman, 2002). The primary synthetic and metabolic enzymes for the endocannabinoid 2-arachidonoylglycerol (2-AG) have been identified as diacylglycerol (DAGL) and monoacylglycerol lipase (MAGL), respectively (Dinh et al., 2002), albeit other enzymes (e.g., ABHD6 and ABHD12) also contribute to 2-AG metabolism (Marrs et al., 2010). In several brain areas, localization of FAAH is primarily post-synaptic whereas localization of MAGL is pre-synaptic (Gulyas et al., 2004), suggesting some degree of functional segregation of signaling pathways for each endocannabinoid.
