is a formaldehyde dehydrogenase with low affinity for alcohol and therefore its role in alcohol metabolism and consumption is as yet unknown. rs145452708 that is located in the region between ADH1B/ADH1C and rs35081954 is a common variant located in intron 1 of ADH1C. ADH1B and ADH1C are alcohol dehydrogenases expressed in the liver and are primarily responsible for the catabolism of ethanol. Variants in ADH1B and ADH1C have previously been associated with various alcohol consumption phenotypes.9, 12, 45
