found significantly higher major depression GRS in those with more severe MDD, as measured in different ways (Fig. 2c). Last, because around half of the major depression cases were identified by self-report (i.e., diagnosis or treatment for clinical depression by a medical professional), we further evaluated the comparability of the 23andMeD cohort with the other cohorts (full meta-analysis excluding 23andMeD, “FMex23”) as detailed in Fig. 2c, Supplementary Table 5 and Supplementary Note. Taken together, we interpret these results as supporting this meta-analysis of GWA results for these seven cohorts.
