A total of 732 ADHD cases passed quality control; 84% of subjects were male, and the mean age was 10.4 years. Most had combined-type ADHD (81%), and the remainder had primarily inattentive (14%) or primarily hyperactive-impulsive ADHD (5%). In the subsample for which information on comorbid disorders was available, 18% had comorbid conduct disorder and 47% had comorbid oppositional defiant disorder. A detailed breakdown by site has been described (8) and is summarized in Table S1 in the online data supplement. After exclusion of common (minor allele frequency >0.01) CNVs, all association analyses were based on 1,562 rare CNVs larger than 100 kb (460 in case subjects and 1,102 in comparison subjects; see Table S4 in the online data supplement). There was no significant difference in the rate at which CNVs >100 kb were called in males compared with females in either case or comparison subjects (data not presented).
